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Jimi's Daily Health Articles

Jimi

Diamond Contributor
Member For 5 Years
This Berry has a Scary-Sounding Name,
But It Helps Fight Cancer

Deadly nightshade is one of the most toxic plants, causing delirium, hallucinations, convulsions and possibly death to the unlucky soul who eats enough of it.

Unfortunately, another plant is often confused with deadly nightshade, yet is not only edible and nutritious, but acts against cancer in many ways.

It's called black nightshade. Here’s what it can do. . .

If it's sweet, it's safe

Black nightshade (Solanum nigrum) is part of a family of plants that includes tomatoes, chili peppers, egg plants and potatoes. All of these relatives of black nightshade are sometimes grouped together as the nightshade vegetables.

Dozens of related plants used to be grouped together under S.nigrum – they were all called black nightshade -- but many are now being reclassified as separate species. S. nigrum is native to Europe and the Mediterranean and is often called European black nightshade.

In the US, S. ptychanthum dominates in the East, and S. americanum dominates in the South. The Great Plains is home to S. interius, and S. douglasii is found in the Southwest.

Sometimes the whole group is referred to as Solanum nigrum complex. Other names for black nightshade are Duscle, Garden Nightshade, Hound’s Berry, Petty Morel, and Wonder Berry.

Unlike deadly nightshade, where the berries grow individually, black nightshade berries grow in bunches. They start out green, then ripen to dark purple-black berries ready to pick in the late summer and fall. They’re safe to eat.

The flavor is said to be sweet with a savory hint, like a cross between a tomato, a tomatillo and a blueberry (Warning: if the berry hasn't fully ripened and doesn't taste sweet, do not eat it).

Although the ripe berries and leaves are consumed by up to a quarter of the world's population, the plant is widely believed to be toxic, probably because of its historic confusion with deadly nightshade (Atropa belladonna).

Nicholas Culpeper, in his Complete Herbal, first published in 1653, wrote, “Have a care you mistake not the deadly nightshade for this [black nightshade]; if you know it not, then you may let them both alone.”

Modern day wild plant authority and author Samuel Thayer assures us, "Through an extensive search of literary sources and consultation with experts, I have been unable to locate a single, credible, documented case of poisoning from the ripe berries of any member of the S. nigrum complex."1

Medicinal uses

The European species of black nightshades were known to the ancient Greeks and Romans, who used them medicinally. In the 1st century AD, Pliny the Elder documented its use against stings, wounds and lumbago (lower back pain).2

In traditional Indian (Ayurveda) medicine, black nightshade infusions are used to relieve fever, stomach complaints and dysentery. The juice is used to treat ulcers and skin diseases. The fruit or leaves are used for asthma, tuberculosis, whooping cough, and liver diseases.

The plant is also part of traditional Chinese medicine, where practitioners believe it acts as an antioxidant and diuretic, possesses anti-inflammatory, liver protective, and anti-fever properties, and can relieve mastitis (a breast tissue infection). Black nightshade is also frequently included in cancer therapy.

Medicinal uses in Africa include antiseptic for eyes and skin, treatment of diarrhea, and as a general tonic for health.

It’s quite a grab bag of medical claims, and we don’t have sufficient evidence for all of these traditional uses. Laboratory studies support some of them. Four rodent studies have tested its effects on the liver and found it protected against scarring (fibrosis), alcoholic liver damage, paracetamol-induced toxicity, and poisoning by cadmium chloride.

Other studies have found black nightshade protects the brain from free radicals generated by physical or psychological stress and has anti-fungal, anti-allergy, anti-inflammatory and anti-convulsant effects.3

That particular group of benefits suggests black nightshade is some kind of antioxidant, and further evidence confirms a much. . .

Suppresses tumor growth

In 2003, South Korean researchers carried out an early study that looked into Solanum nigrum as a potential anti-cancer agent.

They prepared an extract from ripe fruit and tested it on human breast cancer cells grown in a lab culture. It turned out the extract “strongly suppressed” the ability of the cells to grow, and it did so by inducing apoptosis (cancer cell suicide). The researchers also found it was a good scavenger of free radicals.

They concluded that the "extract could be used as an antioxidant and cancer chemo-preventive material."4

The following year, another research group from South Korea tested a different extract from the plant on human colon cancer cells.

Again, they found it was toxic to these cells and induced apoptosis by inhibiting various proteins that are involved with the promotion of tumors. They speculated that the extract "could be used as a chemotherapy agent even at low concentrations."5

Since then there have been over 50 research papers looking at the effect of different extracts of S. nigrum on cancer cells lines. Anti-tumor effects have been found for leukemia, prostate, liver, bile duct, lung, stomach, bladder, pancreas, skin (melanoma), endometrial and cervical cancer through many different cellular pathways and by activation of apoptosis and autophagy.

Autophagy is a cellular process by which misfolded proteins and other cellular debris that could damage the cell are swept away, protecting the cell and promoting its survival.

Reduces tumor weight and volume

Recent studies have looked to mice experiments for confirmation of these in vitro (cell culture) findings.

Two studies were published in 2016. In the first, scientists from Taiwan tested two extracts of S. nigrum on tumor-bearing mice.

Both extracts significantly reduced the volume and weight of the tumors, as well as the expression of CD31, a marker for angiogenesis - growth of the blood supply to the tumor. In addition, the black nightshade extracts inhibited vascular endothelial growth factor (VEGF), which helps feed angiogenesis.

In a further experiment they found human liver cancer cells were inhibited by both extracts and this was correlated with inhibition of AKT/mTOR, an intracellular signaling pathway important in the regulation of the cell cycle.6

In the second study, Malaysian scientists fed a polysaccharide fraction from S. nigrum to mice with breast tumors for ten days.

The treatment inhibited tumor volume by a significant 65% and tumor weight by 40%.

Analysis of blood, tumor, spleen, and thymus found an increase in certain immune cells in the tumor tissue and higher apoptosis in the treated mice. The researchers concluded that tumor suppression came about through boosting immune response. This is in line with previous research which showed the same extract modulated the immune system.7

Shrank tumors in this mice study

The most recent study was published in the Journal of Cancer Research and Therapeutics in 2018.

Here the scientists also looked at the effect of a polysaccharide fraction in mice with liver cancer. They were particularly interested in the expression of caspase-3, a protein which induces apoptosis (cancer cell death), and bcl-2, a family of proteins that can act as a barrier to apoptosis and facilitate tumor development and resistance to cancer therapy.

Mice were given three different concentrations of S. nigrum polysaccharides daily for ten days.

The black nightshade extract reduced the average tumor weight compared to the control group. The tumor inhibition rates were 37.73%, 38.24%, and 42.60%, with rates rising as the dose increased.

The protein expression of caspase-3 (inducing cancer cell death) in S. nigrum groups was higher, but the expression of bcl-2 (prevents cancer cell death) was lower than the control group in a dose-dependent manner.

Other tests indicated an improvement in immune function.

The researchers wrote that black nightshade "possesses obvious cytotoxicity to the tumor and inhibits tumor cell growth."8

All research on black nightshade has been carried out in Asian countries. The only exception was a study by Case Western Reserve University, Cleveland, Ohio. They wrote:

"Our results, for the first time, demonstrate that the S. nigrum extract is capable of selectively inhibiting cellular proliferation and accelerating apoptotic events in prostate cancer cells. S. nigrum may be developed as a promising therapeutic and/or preventive agent against prostate cancer."9

That was published in 2012. Yet in spite of their encouraging findings, neither they, nor any other Western group, has followed up.

Anyone interested in incorporating black nightshade into cancer therapy is unlikely to find an integrative oncologist with experience in using it, but may find it with a practitioner of traditional oriental medicine.
 

Rhianne

Diamond Contributor
Member For 2 Years
ECF Refugee
There really isn't much that's good for you in milk of today, plus you also get bovine growth hormones which isn't good for you either:eek:

The virus and pus really grossed me out! I’m sticking with Califia Better Half. It’s yummy, no sugar, and it’s a mix of almond and coconut milk. It’s delish in coffee! (The Vanilla rocks! Sorry for sounding like an ad!)


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Last edited:

Rhianne

Diamond Contributor
Member For 2 Years
ECF Refugee
Definitely start again....!

I put a big chunk of fresh turmeric root in the morning smoothie, damn that is good stuff....!

Hey, Jimi. Would you know of any brand of Turmeric caps that are good? I’ll prolly take it more regularly if it’s in capsules. I’m admitting my laziness or whatever it is! :teehee:
How ya doing, my friend? :hug: :hug:


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Jimi

Diamond Contributor
Member For 5 Years
Definitely start again....!

I put a big chunk of fresh turmeric root in the morning smoothie, damn that is good stuff....!
I seen fresh in a health food store here,it looked like it was 10 years old and they wanted 24 dollars a pound, wish I could get fresh here that "was" fresh and didn't charge an arm and a leg for
 

Jimi

Diamond Contributor
Member For 5 Years
Hey, Jimi. Would you know of any brand of Turmeric caps that are good? I’ll prolly take it more regularly if it’s in capsules. I’m admitting my laziness or whatever it is! :teehee:
How ya doing, my friend? :hug: :hug:


Sent from my iPad using Tapatalk
Now is a good lower-mid price range with pretty good quality, the Swanson 95 seems to be pretty fair too but i like the Now better:)
I am doing pretty good lately:bliss:,thank you for asking my friend
 

Rhianne

Diamond Contributor
Member For 2 Years
ECF Refugee
Yes I do, but i use it in the more concentrated form Curcumin, I get Now brand and Swanson Curcumin 95 when I can't get the Now. Everyone should take it;)

I was afraid that I messed up and asked inspects instead of you! Thankfully, it’s Friday! :giggle:
I did have the Cucurmin caps but when I ran out, I couldn’t find the brand again. It was Vitboost, iirc. They worked well when I tore my knee and was really messed up for months on end.
Thanks!


Sent from my iPad using Tapatalk
 

Jimi

Diamond Contributor
Member For 5 Years
Excessive Belly Fat Linked to Smaller Brain

If you know you should lose weight, but haven’t quite summoned up the motivation to get the job done, today’s article may give you the extra push you need.

In a large observational study,1 researchers measured body mass index (BMI) and waist-to-hip ratios found in men and women. Those with higher ratios of both had the lowest brain volume. The results were published in the 2019 issue of Neurology, the medical journal of the American Academy of Neurology.

The results don’t amount to absolute proof, but they’re powerful evidence. Here’s an explanation of what it all means. . .

BMI is a basic weight-to-height ratio that is determined by dividing a person’s weight by the square of their height. A BMI above 30.0 puts a person in the obese category.

The waist-to-hip ratio is determined by dividing waist circumference by hip circumference. Therefore, those people with bigger bellies compared to their hips have higher ratios. Men above 0.90 and women above 0.85 are considered centrally obese.

In layman’s terms, being pear-shaped may be bad for your brain. It’s already known that this body shape is connected to other medical problems.

Brain Loss

The study’s lead author Mark Hamer, PhD, of Loughborough University in England, explained the goal of the research.

“Existing research has linked brain shrinkage to memory decline and a higher risk of dementia, but research on whether extra body fat is protective or detrimental to brain size has been inconclusive,” he said.

“Our research looked at a large group of people and found obesity, especially around the middle, may be linked to brain shrinkage.

Researchers observed 9,652 people with an average age of 55. Of that group, about 1,000 participants with high BMI and waist-to-hip ratios had the lowest average amount of gray matter in the brain.

In contrast, the 3,000 participants with healthy weights showed an average amount of gray matter. Interestingly, about 500 participants with a high BMI -- but not an excessively high waist-to-hip ratio -- also had an average amount of gray matter.

You had to be in bad shape (literally) by both measures before brain loss was likely to be seen.

Good to be Gray

Gray matter contains most of your brain’s nerve cells. It’s found in regions involved with self-control, muscle control and sensory perception.

Scientists also believe there’s an association between general intelligence and the volume of gray matter in specific regions of the brain. Not surprisingly, those regions are the same ones implicated in memory, attention and language.2 White matter, somewhat less important for cognition, contains nerve fiber bundles that connect various regions of the brain.

Dr. Hamer explained that while the study found obesity, especially belly fat, was associated with lower volume of gray matter, the finding poses a chicken-or-egg question.

“It’s unclear if abnormalities in brain structure lead to obesity or if obesity leads to these changes in the brain,” Dr. Hamer said. “We also found links between obesity and shrinkage in specific regions of the brain.”3

He concluded that in the future measuring BMI and waist-to-hip ratio may help determine brain health. However, he also noted that further research is warranted.

I’ll just add that being overweight is closely correlated with high blood sugar and diabetes. The latter are known risk factors for dementia.

A Truly Random Group?

A shortcoming of the study was that only five percent of those invited to participate took part, and those who did tended to be in better health than those who did not. The results may not reflect the population as a whole.

When asked for his take-home message, Dr. Hamer said a healthy weight is important, but it’s just one piece of the brain health puzzle.

“We should encourage people to be physically active, not smoke, drink in moderation, eat a healthy diet, and keep blood pressure and cholesterol in check in order to keep the risk of dementia as low as possible,” Dr Hamer advised.

I agree. But even though we may not know what exactly links obesity, brain health and dementia risk, all indications say they’re entwined.
 

inspects

Squonkamaniac
Senior Moderator
VU Donator
Diamond Contributor
Member For 5 Years
I was afraid that I messed up and asked inspects instead of you! Thankfully, it’s Friday! :giggle:
I did have the Cucurmin caps but when I ran out, I couldn’t find the brand again. It was Vitboost, iirc. They worked well when I tore my knee and was really messed up for months on end.
Thanks!


Sent from my iPad using Tapatalk
My name is Dale.....:vino:
 

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