Exposure to e-cigarette vapor fails to induce pneumonia in mouse models

Discussion in '#BANTHIS' started by lordmage, Dec 4, 2019.

  1. lordmage

    lordmage Senior Moderator Staff Member Senior Moderator VU Donator Gold Contributor ECF Refugee Member For 5 Years

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    Washington, DC - December 2, 2019 - Exposure to e-cigarette vapor containing nicotine had no impact on the ability of Streptococcus pneumoniae strain TIGR4 to infect mouse models. The research is published December 2nd in Applied and Environmental Microbiology.

    In light of the booming popularity of e-cigarettes and the rising number of deaths from vaping, a team of researchers from the University of Louisiana at Lafayette set out to determine whether e-cigarettes might boost the risk of pneumonia. "S. pneumonia is the most frequent cause of pneumonia in children five years and under, as well as adults older than 65, and immune-compromised individuals," according to the report. Exposure to smoke from conventional cigarettes is a critical risk factor for pneumonia.

    In the study, the investigators compared the effects on S. pneumoniae of exposure to strawberry-flavored e-cigarette vapor containing nicotine, the same vapor with no nicotine, cigarette smoke, and with no cigarette-related exposure.

    As compared to controls, nicotine containing e-cigarette vapor induced major changes in gene expression of pneumococcus, affecting 264 genes, mostly involved in metabolism and stress response. Nicotine free e-cigarette vapor changed altered expression of just 14 genes, and only modestly, said corresponding author Ritwij Kulkarni, PhD, Assistant Professor of Immunology, University of Louisiana at Lafayette. The latter genes are involved in sugar transport and metabolism. By comparison, cigarette smoke altered expression in 982 genes, also mostly involved in metabolism and stress response.

    "Interestingly, neither nicotine containing nor nicotine free e-cigarette vapor altered the ability of pneumococci to cause lung infection in a mouse model of infection," said Dr. Kulkarni. However, both nicotine-containing e-cigarette vapor and cigarette smoke caused moderate induction of biofilm formation," according to the report.

    "Our work is part of a long series of observations coming from a number of research labs trying to define what effects e-cigarette vapor exposure may have on human health, and to differentiate between the effects of flavoring chemicals and nicotine," said Dr. Kulkarni.

    "Every day on my way to my classroom I see a lot of students vaping," said Dr. Kulkarni. "We don't know the effects e-cigarette vapor has on us or on our microbiome. Since our lab's focus is bacterial respiratory infections, we decided to work on pneumococcus, which is a deadly pathogen and a colonizer of the upper respiratory tract.

    Pneumonia causes about 50,000 deaths annually in the US, making it one of the greatest causes of death by infectious disease. "Exposure to cigarette smoke is a key risk factor for pneumonia because it affects the physiology and immune responses of the respiratory tract and augments the virulence of pathogens colonizing the nasopharyngeal mucosa," according to the report.

    ###

    The American Society for Microbiology is the largest single life science society, composed of more than 30,000 scientists and health professionals. ASM's mission is to promote and advance the microbial sciences.

    ASM advances the microbial sciences through conferences, publications, certifications and educational opportunities. It enhances laboratory capacity around the globe through training and resources. It provides a network for scientists in academia, industry and clinical settings. Additionally, ASM promotes a deeper understanding of the microbial sciences to diverse audiences.
    source: https://eurekalert.org/pub_releases/2019-12/asfm-ete112119.php

    Full data set here: https://aem.asm.org/content/early/2019/11/11/AEM.02125-19
     
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  2. Anibird

    Anibird Platinum Contributor Member For 1 Year Reddit Exile

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    How did the mice vape? Was a researcher vaping and blowing shotguns to the mice?

    Seriously though it's a good article. Unfortunately the people that need to read it probably won't.
     
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  3. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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    I’ve seen another study about diacetyl (I think) and they were pumping vapor into the mice tanks. It was so fucking cruel. They prolly did something similar here. The mice would’ve preferred teeny pods to hit on, though.
     
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  4. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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  5. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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  6. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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    it is the human infestation.
     
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  7. gsmit1

    gsmit1 Platinum Contributor Member For 2 Years

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    Yes, but they left out the part about how the mice started trying to order stuff from China.
     
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  8. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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    Shiny stuff!
     
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  9. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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    Long live the meeses! Hope you’re feeling better, Cromwell.
     
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  10. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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    fully recovered thanks for asking.
     
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  11. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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    I’m glad. I wasn’t feeling good for about two or three weeks. It was my stomach first, then it just felt like a bad cold.
     
  12. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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    This was all GI with fever and such. About 1 week start to finish.
     
  13. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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    You’re lucky. Mine has been making me feel blech for weeks now. I haven’t gone to a doctor since I don’t really want antibiotics. But if it doesn’t go away, I’ll go.
     
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  14. The Cromwell

    The Cromwell The Frugal Vapist VU Donator Diamond Contributor Member For 4 Years

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    I was well beyond bleah for about 4 days.
    I think I died and then got better.
     
  15. Rhianne

    Rhianne Diamond Contributor ECF Refugee

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    I’ve been sick like that once or twice, it’s horrible. But this time I didn’t have a real fever. It’s just cold symptoms, sore throat/cough, and tiredness.
    I was starting to wonder if I caught the teen illness since I’ve been so scornful of it!
     
  16. lordmage

    lordmage Senior Moderator Staff Member Senior Moderator VU Donator Gold Contributor ECF Refugee Member For 5 Years

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    you are an alien after all so a new husk had to be grown :D
     
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