There's nothing wrong with other colored keys, the variety really does come down to personal preference. Kailh also offer mechanical switches. They may not be exactly like cherry mx but so far they've been pretty solid. Got a tesoro excalibur with the kailh switches for a family member around 9mo ago when they were on sale on amazon. At the moment they have the standard excalibur on sale for around $70.
The way you describe it sounds like your keyboard is on top of your desk with your monitor as opposed to on a keyboard tray positioned a bit lower. I wonder if position isn't part of what's making your wrists a bit sore? Something to consider in part of your approach to fatigue.
In terms of mice, you might try to find out if they're optical or laser. Usually optical are preferred for gaming, laser mice on soft/cloth pads tend to vary in their tracking/movement. Not to say laser aren't usable, I game now and then and use a laser mouse (I'm sure there were gasps somewhere in the gaming community lol). Games like skyrim (which appears similar to warframe, I've never played that one), far cry, call of duty, crysis. A few rpgs but most are fps types. I'm no esports champion gamer or anything, works well enough for the way I play. I don't notice myself missing shots or anything because of it.
Hopefully you can try out the keyboards and things with your wife so she can weigh in. Usually if momma ain't happy ain't no one happy
Good luck on your search.