I got 3 of the regular DNA75's and 3 DNA75C's. If you're a tinkerer or a high ohm vaper (.8 to 2.5 ohm builds) the DNA75C is a much better mod. If you're not going to try new themes and have no interest in that and vape considerably lower resistance builds. The DNA75 is better for me only because it's cheaper. The difference is that the DNA75C is capable of supplying more voltage to the atomizer than the DNA75. (9 Vdc versus 6 Vdc). I love my DNA75C's...I'm old and my vision sucks. No problem with the 75C...just enlarge the theme's text and rearrange a few fields. One thing I would recommend for either chip, get a mod that uses 2 - 18650's, you're going to want the battery life. I've got a Lost Vape Therion and Paranormal for my dual battery 75's and a Therion squonker. The squonker always seems to be needing a charge. The dual battery mods, vaping at 35 to 40 watts, charge them every other day.