Fwiw I hate reddit. They're always the same, it starts off with an original concept or question, one person tries to answer, the next couple tell the op what a dumbass they are and then the next 100 replies go so far off the rails and have me laughing so hard I forget why I started reading it.
I get it every now and then even when switching up ejuice. My two favorites are tobacco type flavors (ry4 included) and fruit flavors. Sometimes creamy ones but the fruit ones the flavors seem to start running together more often than not. Banana, berry, pineapple, doesn't seem to matter much. Even with drinking water and sniffing coffee, I'm already a coffee drinker and get plenty of things like salsa since I like spicier foods. Some people have good luck with straight water to clear things up, others coffee, some people iced tea does the trick. Some of the flavored drinks though (anything aside from water) can impact vape flavor and either enhance it or mute it to where it tastes like just huffing in steam from the shower.
It's true about scent fatigue, when I worked in an auto shop the smell of the place never bothered me. Making a quick stop in the shop over the weekend after being away from the smell and with the doors closed up it was a lot more pungent. Like anything else the body adapts, it's difficult to get the body to stop adapting to something we don't want it to. Sensory overload can cause the body to respond, shutting certain things out. Much like watching a movie at home with friends, it doesn't seem obnoxiously loud. Turn the tv back on first thing in the morning at the same sound volume and you'll probably be thinking damn, were we deaf?