22mg in a GS Air, Nautilus, iSub with the 2 Ohm coils etc. would be a real killer. I guess you were using a 1st gen tank with that? Either that or you have a really really hairy chest and previously ripped the filters off your Marlboro Reds ha ha.
First gen, this was three years ago and it was technically a clearo-tank. I still use those--the Kanger T3, now the T3S--but 22 mg these days would have my butt on the floor clutching my stomach and trying not to vomit.
Really, I notice very little difference between the Kanger T3S and a good mouth to lung tank with the air set as tight as I like it (extremely tight). 1 mg is correct for me in both.
Devices also weren't nearly as advanced as they are nowadays, the Vamo V2 was in style and about the best thing going. And not cheap.
When I started, I was at 12 mg on a cartomizer, and that just wasn't cutting it worth diddly on the cigalikes. I stepped to an eGo-like device with a 3.7 V set point, and kept stepping up the nic until I was satisfied.
Today the experience should be very different, but I wouldn't be surprised if heavy smokers, or smokers of full-flavor cigarettes, might require 12 mg/ml liquid to quit smoking before dropping back.
However, my cousin is still at 12 mg/ml on a TC tank, so there are certainly some people who enjoy the hit. It'd knock me out!