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How embryos shape their limbs: key discovery of “genetic brakes”

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Researchers at Université de Montréal and the IRCM found that two Polycomb protein systems work together to switch off early limb-development genes at the right time in mice, allowing later developmental programs to proceed normally. Disrupting both systems severely impairs limb formation and causes major gene-expression errors. [nouvelles.umontreal.ca]

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