All this concern over your coils, forgot to ask what batteries you're using.
And that much of a change in res is just wrong. Sounds like loose connections, either the posts or the various pieces of the RDA.
And some chip sets will "reduce power" with lowering battery voltage, but I haven't noticed that with the D2. Can't check immediately either.
Some of your voltage comments confuse me so here's the deal...
18650s - They have a max safe voltage charge of 4.2v. There appears to be a nominal voltage drop of about 0.7v under load, so most reg mods cut off around 3.2v min so the battery doesn't go below 2.5v.
Too low may cause damage and even make them unrecoverable without a "conditioning" charger.
Regulated Mods - My favorite term for this topic is "chip trickery" but it's just the manipulation of energy.
Energy is quite manipulable, picture high voltage transmission lines (125,000v) or a 50Kv taser.
The mod takes the voltage and transforms it either down (buck circuit) or up (boost circuit) to produce the requested wattage for that resistance and regulates it to keep it steady (thus... regulated mod).
The D2 has a max output voltage spec of 8.0v. But you'd need a higher res coil to make that calculation work (Ohm's Law) and a fair bit of wire to not fry it. Don't think I see more than five-ish even up around 100w with lower 0.2s.
Testing, just for grins, but you should get similar numbers...
Grabbed a 0.387 (Ti 0.4) and the D2 shows 5.33v at 75w (power mode just for the higher W's.
The i100w shows 6.2v at 100w.
I can't check it on the xCube for 180w, as I'd have to fire it to read the volts... and the Ti head wouldn't handle the wattage.