I Don't yet have a DNA250 myself due to not needing 250W, but do have 4 DNA200's and a DNA75 in the collection, and I have to disagree that they are only for people with time and patience to program them, and also are overpriced.
A lot of Evolv devices now come with profiles pre installed, my SDNA 75 come fully set up with profiles from soft- to hard+. I could of kept the mod set up this way, as it had the wire types I used, and also the profiles were OK, but I wanted to change the preheat as they was all set at 75W, but with low to high punch settings.
I essentially kept the same layout, but just changed the preheat to around 30W for soft-, and the full 75W for Hard+. It did work very well out of the box though with the profiles made my Daniel from youtube. Anyone could of used this mod as it was, without having to use Escribe at all, and a fair few DNA200's come with profiles now too so work well out of the box.
The only protection the DNA200 was missing was reverse polarity protection, but this is because it was designed for use with a 3S Li-Po so was not needed, same with the 250 as explained in the datasheet here- "DNA 250 is designed for battery packs that are permanently installed into the device, or battery packs that install using an insulated, polarized connector rated for at least 30 amps. If the battery pack is installed with the polarity reversed, the fuse will blow to protect the battery pack, board and user. "
So there is still protection to the board in case of reverse polarity, which is a replaceable fuse, just not the type of reverse polarity protection we are now used too.
The DNA75 and DNA60 has reverse polarity protection due to being designed with replaceable batteries in mind.
I think they are top notch boards, and they get a lot of use in my collection. Sure, I do use cheaper mods, and enjoy them a lot too, but think the boards by Evolv are fantastic.