My dogs have been seeing this vet for years, very hard when you live in a small town and not many options. Reading online while rare some dogs do develop complications from their shots like Pearl is having usually with young puppies and older dogs. Brain swelling due to the shots, like an allergic reaction except this reaction doesn't go away. Some dogs do recover, but not fully. Really not the Vets fault or the serums fault, just some dogs can't handle these shots. Pearl has had all her shots for years, and this is the first time anything has happened, my husband is so upset, we have to give our animals these shots, required here for registration and now we have no choice but to put her down.