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Jimi

Diamond Contributor
Member For 5 Years
Tumor-Targeting Gut Bacteria
“Turn Off” Melanoma

A funny thing is happening in the world of cancer treatment. It’s subtle. People who don’t read about cancer on a regular basis may not notice it.

But ever so slowly, the pendulum on treatment is swinging back around from the mania for invasive drugs and procedures to a focus on the immune system.

Instead of coming up with weapons to directly kill cancer cells, immunotherapy helps the immune system do the killing. It seeks to arm the body’s immune system with tools needed to fight specific aspects of cancer.

Today I have an especially fascinating example of the new breakthroughs in immune therapy.

And in contrast to the most powerful high-tech and chemical medical creations the world has ever seen, this pivots toward the tiniest, most basic of all healing organisms: your gut bacteria.

The Jekyll-and-Hyde nature of your gut bacteria

One immunotherapy treatment uses drugs called immune checkpoint inhibitors, which are able to block proteins produced by cancer cells that protect them against immune cells.

But not all types of cancer respond to treatments using immune checkpoint inhibitors. Side effects from these drugs can also be severe.

So it’s fascinating and downright promising that a new study from Nature Communications documents the discovery of a link between gut bacteria and anti-tumor immunity. Building on this research, scientists should be able to pinpoint people most likely to benefit from cancer treatment through immune checkpoint inhibitors.

Anti-tumor immunity no longer wishful thinking

It all starts with the way gut bacteria interact with the immune system to fight cancer. In the study, multiple strains of gut bacteria were identified as helping to slow the growth of melanoma in mice.

The researchers were part of a large international team that included collaboration with three hospitals. They used mice that lack something called the RING finger protein 5 (RNF5), which helps cells remove rogue proteins. The research revealed that among the RNF5-deficient mice, those with healthy immune systems and intact gut microbe populations were able to stop melanoma – a deadly, highly aggressive cancer.

Incredibly, if those same RNF5-lacking mice were housed with mice that did not lack the protein, the animals lost their ability to fight off the melanoma tumors. The same thing happened if the RNF5-lacking mice were treated with antibiotics. Both examples show the enormous role microbes play when it comes to antitumor immune defenses, and how susceptible they are to environment.

The investigators even highlighted a signaling pathway known as unfolded protein response (UPR) as the link between the gut bacteria and the antitumor fighting ability of the immune system. UPR appears to be a solid marker for selecting patients with melanoma who are more likely to benefit from immune checkpoint therapy.

According to senior study author Ze'ev Ronai, a professor at Sanford Burnham Prebys in La Jolla, California, the results of the study pinpoint a group of bacterial strains “that could turn on antitumor immunity and biomarkers that could be used to stratify people with melanoma for treatment with select checkpoint inhibitors.”

They concluded the components of the immune system in the gut, plus the reduction in UPR in both immune and gut cells, played a role in activating the immune cells.

Melanoma was targeted in part because it is the deadliest of all the skin cancers, even though it only accounts for about one percent of skin cancer diagnoses. Immune checkpoint inhibitors have already had a striking effect on boosting survival rates for melanoma. But of all the types of skin cancer, melanoma is the most likely to invade nearby tissues. Once that happens, the risk of death rises dramatically.

The investigators took the research one step further and identified 11 strains of bacteria in the RNF5-lacking mice. When they transplanted those strains to mice with no gut bacteria, an entire antitumor response was triggered and melanoma tumor growth decreased.

You’ll never replace the real thing

So, what does this mean for you if you’re worried about melanoma? If you’re interested in immunotherapy, at the very least start the conversation with your doctor about getting tested to see if your gut microbiome makes you a strong candidate. Such tests and routes to ideal-candidate treatment may still be in the uncertain future, but there could be studies you can join before a specific testing strategy is public.

In the meantime, this gives the rest of us further reason to eat a diet that supports a healthy gut. New findings presented at the 2019 Annual Meeting for the American Association for Cancer Research support the idea.

Researchers looked at patients just starting treatment and determined that a high-fiber diet, which leads to more diverse intestinal bacteria, is linked to a stronger response to Anti-PD-1, an immunotherapy that helps the immune system recognize cancer cells as dangerous.

In this study, researchers collected fecal samples from over 100 people receiving treatment for melanoma and compared tests for gut bacteria to a survey each participant completed about their diets. Their findings show a high-fiber diet, abundant in vegetables, fruits, and whole grains, was associated with the types of bacteria previously linked to better response to anti-PD-1 therapy.

Interestingly, the researchers also found that roughly 40 percent of study participants were taking a probiotic supplement, but that probiotic use was linked to a lower diversity of the gut microbiome. This may not be a bad rap on the probiotics themselves, as it’s possible those who took probiotics did it instead of eating high-fiber foods, as opposed to taking the supplement with their high fiber foods.

Separately, the researchers looked at a group of almost 50 patients who supplied information on diet and gut microbiome and determined those on a high-fiber diet were about five times more likely to respond favorably to anti-PD-1 treatment than those who ate a low-fiber diet.

Better food = Better outcomes, always

I’m looking forward to findings from the follow-up research to the first study I mentioned. The upcoming results will be focused on distinguishing the antitumor molecules produced by the gut bacteria of the mice that fought off melanoma.

Researchers plan to run tests on the “antitumor powers” of those molecules to figure out which probiotics might increase the effectiveness of those same molecules in people with melanoma.

But at the end of the day, the truth is simple. A high-fiber diet, heavy on a variety of plant-based foods, leads to more diversity in your gut flora, and more diversity strengthens your immune system, and that gives you better outcomes in the prevention and treatment of cancer.
 

Jimi

Diamond Contributor
Member For 5 Years
Great to know, I just bought some raw local honey that is so creamy. It’s expensive but I’m not eating sugar, and I’m worth it! Lol
Howdy, Jimi. Great articles, my friend. :blowkiss: :hug:


Sent from my iPad using Tapatalk
Always stick to the local honey, Some store bought honey is cut with high fruitrose corn syrup, very deceiving:gaah:
 

Jimi

Diamond Contributor
Member For 5 Years
This Gift of the Grape Can Protect Memory
and May Fight Depression


A nutrient that gets a lot of attention for slowing down aging is now also being recognized for the good things it does for your brain and mood.

Those good things include improving memory, protecting neurons from the kind of destruction that leads to Parkinson’s disease, and also potentially stopping the cellular processes that lead to depression.

The nutrient – resveratrol – is a natural chemical found in grapes, berries and peanuts and is available as a supplement, as you no doubt know. It’s touted as a reason to drink wine, although alcohol comes with enough negatives that I don’t recommend it as a means of getting resveratrol.

Research shows that it can defend the brain’s neurons from oxidative stress and inflammation. And now a study at the University of Buffalo has examined how resveratrol can alter the workings of brain cells in ways that could push back against depression. Keep reading for more details. . .

The Buffalo researchers focused on how stress and the release of the stress hormone corticosterone affects the brain. They say that when we’re over-stressed, we get too much of this hormone among our neurons, and the hormonal overdose can lead to depression and other mental problems.

These two mood problems are extremely common. According to the Anxiety and Depression Association of America, the two disorders affect anywhere from 16 to 40 million Americans.

Right now, the most widely used drugs for depression are meant to target the function of the neurotransmitters serotonin or noradrenaline. But this pharmaceutical ploy usually doesn’t work too well. It’s estimated that less than a third of people who take these drugs get complete relief from their depression.

However, the Buffalo research shows that resveratrol attacks depression a different way – by changing the function of an enzyme called PDE4 and keeping it from acting in ways that can bring on the awful emotions that characterize depression in response to stress hormones.1

Other studies that have looked at the relationship between inflammation and depression produce results that also show that resveratrol helps improve your mood. Lab tests at the University of South Carolina indicated that the nutrient can decrease inflammatory actions by the immune system that may bring on the distressing feelings of depression.2

Defends Your Memory

Meanwhile, tests on how resveratrol affects brain function have turned up impressive benefits. A study at Texas A&M demonstrates it can improve learning abilities and memory.

These tests indicate that resveratrol can lead to healthier neurons in the brain’s hippocampus, an important memory center. The tests indicate that it may:3

  • Help provide better blood circulation and supply of nutrients to the hippocampus.
  • Increase the growth of new neurons.
"The study provides novel evidence that resveratrol treatment in late middle age can help improve memory and mood function in old age," says researcher Ashok Shetty.

Boost Your BBB

In another area of the brain, the blood-brain barrier, resveratrol also plays an important role. You may remember the “BBB” keeps harmful toxic substances and inflammatory immune cells out of the brain.

A study at Georgetown University Medical Center shows that by reinforcing the integrity of the blood-brain barrier, resveratrol limits inflammation that could otherwise damage neurons and worsen the memory deficits caused by conditions like Alzheimer’s disease.4

The Georgetown scientists say their analysis shows that when this barrier becomes leaky, destructive immune cells are allowed passage into brain tissue and can wreak havoc.

“(Our) findings suggest that resveratrol imposes a kind of crowd control at the border of the brain. The agent seems to shut out unwanted immune molecules that can exacerbate brain inflammation and kill neurons," says researcher and neurologist Charbel Moussa, MD.

"These are very exciting findings because it shows that resveratrol engages the brain in a measurable way, and that the immune response to Alzheimer's disease comes, in part, from outside the brain."

Problems with Absorption and Bioavailability

One big challenge in all of these studies is to find ways to get significant amounts of resveratrol into the brain and other parts of the body where it can do the most good. Researchers are divided about how well the body absorbs resveratrol and how much is needed for the brain and other organs to benefit.

For instance, a lab study in Asia shows that receiving resveratrol in what are called “liposomes” could be effective for Parkinson’s disease.5 Liposomes are tiny vesicles – almost like droplets – made of special kinds of fats that can readily enter the body’s cells. Without the liposomes, the Asian researchers question whether resveratrol therapy for Parkinson’s would work.

These days quite a number of supplement brands offer liposomal forms of various nutrients.

Still, other scientists say you don’t need much resveratrol to reap significant benefits. In one study I’m familiar with, smaller doses of resveratrol were actually more beneficial for the brain than large doses. So I’m not sure you need to pony up the extra bucks for liposomal resveratrol.
 

Jimi

Diamond Contributor
Member For 5 Years
Here's another breathing exercise.....how many of you have done the first one I posted, as vapers "YOU SHOULD"

Just as meal-to-meal consistency is important, if you are to continue healing your physical body, consistent thought-to-thought awareness is required to emotionally re-pattern.

Our energy level, digestive wellness, metabolism, and state of mind can be dramatically improved by the way we breathe.

Slow, deep breathing helps to regulate pH by alkalizing the body, which allows for easier elimination of acidic poisons and less leaching of necessary minerals required to heal. This leads to much better sleep and less anxiety.

It also activates your parasympathetic nervous system helping you recover the balance between the two branches of the nervous system - parasympathetic (rest and recover) and sympathetic (fight-flight-freeze) - which gives your body a better chance to recuperate, regenerate, and heal.

So, twice a day we want you to incorporate five minutes of deep breathing to offer your nervous system, brain, thyroid, and adrenals advanced support.

Because the breath is the gateway and the remote control of the nervous system, you can always use it as a powerful tool to pull you out of sympathetic dominance (fight-flight-freeze) and to pull you into parasympathetic dominance (rest-digest-heal) whenever you feel stressed or triggered.

When you’re healing from adrenal fatigue, you need more oxygen in order to continue converting your food into fuel efficiently as it works in combination with glucose and thyroid hormone (T3) to create more readily available energy to your cells.

The simple act of recoding the way you breathe will increase the bioavailability of oxygen, which your body will use to make energy for you.

Breathing strategically is not optional when you desire to improve brain, thyroid, adrenal, and nervous system function. It’s essential, because all 37.2 trillion living cells generate energy during the process of aerobic respiration.

Doing the breathing technique below from The Adrenal ReCode program will allow your cells to consume more oxygen and produce more carbon dioxide (CO2) as waste. This makes breathing an excellent, safe detoxifier while also creating energy-rich ATP (adenosine triphosphate), the substance that is broken down to release energy and drive the necessary cellular processes you need to make and have energy, good moods and ultimately to thrive.

The deeper you breathe, the more oxygen you get to your tissues, the more rapid and complete your healing process will be.

Tip #4: Breathe Stress Away
ACTION ITEM

Try to take two, 3-5 minute breathing timeouts twice a day to recode your breath.

Alternate Nostril Breathing

When possible, do this breathing exercise before you go to bed.

Alternate Nostril Breathing is a powerful breathing technique used in yoga for stress relief and to balance the left and right hemispheres of the brain, which ultimately allows your creative mind and your logical mind to work in complete harmony – giving you more access to all of YOU.

It also helps us to integrate (& digest) unwanted negative emotions and stress so that they are not stored in the body (which we talk about in Part 2 of The Adrenal ReCode). This breathing exercise is excellent to use in and of itself but is especially beneficial before bed if you have trouble sleeping.

By emphasizing and extending the exhale, you stimulate the parasympathetic nervous system to slow down your heartbeat, calm your nerves, and relax your digestive system; promoting elimination both physically and emotionally.

  1. Place the pad of your right thumb over the outside of your right nostril.
  2. Then, place the pad of your right index finger [aka ring finger] over the outside of your left nostril.
  3. Now, press your thumb down to close off the right nostril.
  4. Gently and fully inhale through the left nostril for a count of 4.
  5. Hold your breath for a count of 6.
  6. At the count of 6, use your ring finger to close your left nostril, lift your thumb to open your right nostril, and exhale through the right nostril for a count of 8.
  7. Then inhale through the right nostril for a count of 6.
  8. At the count of 6, use your thumb to close off your right nostril, lift your ring finger to open the left nostril, and exhale through your left nostril for a count of 8.
  9. Continue repeating this Alternate Nostril Breathing pattern of inhaling to the count of 4 and exhaling to the count of 8 for three full rounds.
  10. After several days, work up to expand your pattern to inhaling to the count of 6 and exhaling to the count of 12.
Watch our Alternate Nostril Breathing video here.
 

Jimi

Diamond Contributor
Member For 5 Years
Popular Anti-Aging Supplement
Attracts Mainstream Support

These days, it seems everyone is seeking the proverbial fountain of youth or an effective “anti-aging pill” to add years to their lives – and help them feel better and look younger, too.

I have a dog in this fight, as I edit a newsletter called Aging Defeated, and our sister company, Green Valley Natural Solutions, offers several anti-aging supplements.

It’s a fascinating field with a lot of amazing new developments, and additional discoveries almost every month.

One of the most popular anti-aging nutrients (not offered by Green Valley) has received enthusiastic support from a Harvard scientist and his team. . .

Turning back the clock on your mitochondria

The story begins with mitochondria, the tiny “batteries” that power our cells. They become lazy, sloppy, and broken down as we age. One prominent theory claims that decaying mitochondria are the key driver of aging.

A coenzyme called nicotinamide adenine dinucleotide (NAD) is a key player in mitochondrial health and the production of cellular energy. Many consider NAD nearly miraculous.

NAD is often written NAD+, which represents its oxidized form.

But you can’t take NAD as a supplement

It’s not helpful to take NAD+ as a supplement, because it’s not bioavailable. One solution has been to take a precursor called nicotinamide riboside (NR), a naturally occurring form of vitamin B3 found in a few select foods. NR is probably the most popular NAD-boosting nutrient among supplement companies.

NR taken by mouth increases your levels of NAD+, the molecule that participates in numerous metabolic pathways and is a key player in other important processes, such as DNA repair.

As you get older, your NAD+ levels drastically plummet, accelerating the aging process.

Animal research suggests it’s possible to reverse mitochondrial decay by boosting NAD+ levels. Higher NAD+ levels can extend life in yeast, worms, and mice. High levels seem to rejuvenate mitochondria.

Other studies point to stronger muscles and improved cardiovascular function, brain function, and glucose uptake.

Two animal studies showed that NR significantly reduced cognitive decline.1,2 Because cognitive loss greatly affects quality of life in old age, this alone would be enough reason to supplement with it.

The NAD+ story takes flight

The NAD story hit the front pages in 2013 after Harvard’s David Sinclair, a full professor, and his colleagues published a second high-profile paper.

His first, from the mid-2000s, discussed research showing that resveratrol mimics the anti-aging effects of calorie restriction in yeast and mice. As you may know, such fasting is a powerful tool for improving health. If a mere pill can achieve similar effects, without cutting back on food intake, it’s an exciting development.

Sinclair’s more recent article reported that mitochondria in the muscles of elderly mice returned to peak efficiency after just one week of nicotinamide mononucleotide (NMN) injections, which boost NAD levels.

However, muscle strength didn’t improve – at least not that fast. Researchers concluded that one week wasn’t long enough to accomplish that, even though age-related mitochondrial decay was reversed almost immediately.

NMN is available as a consumer product, but Sinclair’s report also sparked excitement about NR, which was already available as a patented supplement called Niagen and had the desired effect of boosting NAD+.

The reported glories of NAD

Certain “longevity genes” called sirtuins regulate key cellular processes related to the aging and death of cells, and to energy production as well. But they need NAD to accomplish this.

NAD and sirtuins are crucial for repairing DNA damage.3

Animal studies also link NAD to higher energy levels, chromosome stability, DNA repair, cell signaling, brain health, longer telomeres, and overall longevity.

It’s possible that NAD boosters work synergistically with supplements like resveratrol (found in grapes and some other foods) to rejuvenate mitochondria and fight diseases of aging. At least, some companies are banking on it, though it’s still not certain.

Likewise for pterostilbene, a resveratrol-like substance found in blueberries and grapes. It’s like an extra-potent version of resveratrol. A 2017 study found that pterostilbene combined with NR boosted NAD+ levels, on a dose-dependent basis.4

That’s why a very successful NAD-boosting supplement paired NR with pterostilbene. And it sold like beer at a ballpark on the Fourth of July.

It truly does sound like the “fountain of youth” – the linchpin of energy metabolism. And the marketers have some pretty good evidence.

Best laid plans of mice and men…

As the mountain of research grows, half a dozen Nobel laureates and other prominent scientists are working with companies to produce and sell dietary supplements containing NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

As often happens with supplements, they’ve also attracted their fair share of detractors. The supplements seem to be generally well tolerated based on six to eight weeks of use, but researchers are still undecided as to whether NR actually improves human health.

It’s important to remember that not everything that works in mice works the same way in humans, which is why we need human trials. And test tube data using lab-cultured cells provides even weaker evidence than animal studies.

The current crop of NAD+ boosters lacks human trials at this time.

There’s also been some speculation, based on a mouse study, that boosting the NAD pathway (that is, the activity of NAD) might accelerate the growth of glioblastoma, an aggressive brain cancer. Boosting the NAD pathway might slow down aging while simultaneously fueling cancer growth, according to Versha Banerji, a clinician-scientist at the University of Manitoba.

We looked into this and found the mouse study did not involve NR and in fact didn’t demonstrate much of anything of relevance to humans or NAD. Much, much more study would be needed.

Having said that, I don’t recommend this or other anti-aging supplements to people who have cancer. They do, after all, accelerate cell growth and we just don’t know enough yet about the effects these nutrients might have on cancer.

Obviously the goal is to figure out how to age well – without increasing cancer risk.

How excited should we be about NR and NAD+?

It’s easy to say that if you were a middle-aged mouse, you’d probably do almost anything to get your hands on some NR supplements.

Even before Prof. Sinclair’s 2013 paper, a 2012 paper showed that mice given NR in conjunction with a high-fat diet gained 60% less weight than those on the same diet without NR.

Plus, all of the mice taking NR showed increased energy levels, and none of them showed any symptoms of diabetes.

Some human studies, please! Given the growing buzz about NR and NAD, additional research will likely be forthcoming soon.
 

Rhianne

Diamond Contributor
Member For 2 Years
ECF Refugee
Popular Anti-Aging Supplement
Attracts Mainstream Support

These days, it seems everyone is seeking the proverbial fountain of youth or an effective “anti-aging pill” to add years to their lives – and help them feel better and look younger, too.

I have a dog in this fight, as I edit a newsletter called Aging Defeated, and our sister company, Green Valley Natural Solutions, offers several anti-aging supplements.

It’s a fascinating field with a lot of amazing new developments, and additional discoveries almost every month.

One of the most popular anti-aging nutrients (not offered by Green Valley) has received enthusiastic support from a Harvard scientist and his team. . .

Turning back the clock on your mitochondria

The story begins with mitochondria, the tiny “batteries” that power our cells. They become lazy, sloppy, and broken down as we age. One prominent theory claims that decaying mitochondria are the key driver of aging.

A coenzyme called nicotinamide adenine dinucleotide (NAD) is a key player in mitochondrial health and the production of cellular energy. Many consider NAD nearly miraculous.

NAD is often written NAD+, which represents its oxidized form.

But you can’t take NAD as a supplement

It’s not helpful to take NAD+ as a supplement, because it’s not bioavailable. One solution has been to take a precursor called nicotinamide riboside (NR), a naturally occurring form of vitamin B3 found in a few select foods. NR is probably the most popular NAD-boosting nutrient among supplement companies.

NR taken by mouth increases your levels of NAD+, the molecule that participates in numerous metabolic pathways and is a key player in other important processes, such as DNA repair.

As you get older, your NAD+ levels drastically plummet, accelerating the aging process.

Animal research suggests it’s possible to reverse mitochondrial decay by boosting NAD+ levels. Higher NAD+ levels can extend life in yeast, worms, and mice. High levels seem to rejuvenate mitochondria.

Other studies point to stronger muscles and improved cardiovascular function, brain function, and glucose uptake.

Two animal studies showed that NR significantly reduced cognitive decline.1,2 Because cognitive loss greatly affects quality of life in old age, this alone would be enough reason to supplement with it.

The NAD+ story takes flight

The NAD story hit the front pages in 2013 after Harvard’s David Sinclair, a full professor, and his colleagues published a second high-profile paper.

His first, from the mid-2000s, discussed research showing that resveratrol mimics the anti-aging effects of calorie restriction in yeast and mice. As you may know, such fasting is a powerful tool for improving health. If a mere pill can achieve similar effects, without cutting back on food intake, it’s an exciting development.

Sinclair’s more recent article reported that mitochondria in the muscles of elderly mice returned to peak efficiency after just one week of nicotinamide mononucleotide (NMN) injections, which boost NAD levels.

However, muscle strength didn’t improve – at least not that fast. Researchers concluded that one week wasn’t long enough to accomplish that, even though age-related mitochondrial decay was reversed almost immediately.

NMN is available as a consumer product, but Sinclair’s report also sparked excitement about NR, which was already available as a patented supplement called Niagen and had the desired effect of boosting NAD+.

The reported glories of NAD

Certain “longevity genes” called sirtuins regulate key cellular processes related to the aging and death of cells, and to energy production as well. But they need NAD to accomplish this.

NAD and sirtuins are crucial for repairing DNA damage.3

Animal studies also link NAD to higher energy levels, chromosome stability, DNA repair, cell signaling, brain health, longer telomeres, and overall longevity.

It’s possible that NAD boosters work synergistically with supplements like resveratrol (found in grapes and some other foods) to rejuvenate mitochondria and fight diseases of aging. At least, some companies are banking on it, though it’s still not certain.

Likewise for pterostilbene, a resveratrol-like substance found in blueberries and grapes. It’s like an extra-potent version of resveratrol. A 2017 study found that pterostilbene combined with NR boosted NAD+ levels, on a dose-dependent basis.4

That’s why a very successful NAD-boosting supplement paired NR with pterostilbene. And it sold like beer at a ballpark on the Fourth of July.

It truly does sound like the “fountain of youth” – the linchpin of energy metabolism. And the marketers have some pretty good evidence.

Best laid plans of mice and men…

As the mountain of research grows, half a dozen Nobel laureates and other prominent scientists are working with companies to produce and sell dietary supplements containing NAD+ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).

As often happens with supplements, they’ve also attracted their fair share of detractors. The supplements seem to be generally well tolerated based on six to eight weeks of use, but researchers are still undecided as to whether NR actually improves human health.

It’s important to remember that not everything that works in mice works the same way in humans, which is why we need human trials. And test tube data using lab-cultured cells provides even weaker evidence than animal studies.

The current crop of NAD+ boosters lacks human trials at this time.

There’s also been some speculation, based on a mouse study, that boosting the NAD pathway (that is, the activity of NAD) might accelerate the growth of glioblastoma, an aggressive brain cancer. Boosting the NAD pathway might slow down aging while simultaneously fueling cancer growth, according to Versha Banerji, a clinician-scientist at the University of Manitoba.

We looked into this and found the mouse study did not involve NR and in fact didn’t demonstrate much of anything of relevance to humans or NAD. Much, much more study would be needed.

Having said that, I don’t recommend this or other anti-aging supplements to people who have cancer. They do, after all, accelerate cell growth and we just don’t know enough yet about the effects these nutrients might have on cancer.

Obviously the goal is to figure out how to age well – without increasing cancer risk.

How excited should we be about NR and NAD+?

It’s easy to say that if you were a middle-aged mouse, you’d probably do almost anything to get your hands on some NR supplements.

Even before Prof. Sinclair’s 2013 paper, a 2012 paper showed that mice given NR in conjunction with a high-fat diet gained 60% less weight than those on the same diet without NR.

Plus, all of the mice taking NR showed increased energy levels, and none of them showed any symptoms of diabetes.

Some human studies, please! Given the growing buzz about NR and NAD, additional research will likely be forthcoming soon.


Too bad you don’t get nicotinamide from nic vaping!


Sent from my iPad using Tapatalk
 

Rhianne

Diamond Contributor
Member For 2 Years
ECF Refugee
That's a good daily amount, some would say too much but I take 25000 units a day plus getting 4 to 6 hours of direct sun a day;) so many are defecient

I’ve been staying out of the sun since I’m really fair skinned, so I figured I’d be deficient. For now I’ll take one a day, then maybe every other day. I’m not really getting that much direct sunlight, though. Hope the D3 will make up for it.


Sent from my iPad using Tapatalk
 

inspects

Squonkamaniac
Senior Moderator
VU Donator
Diamond Contributor
Member For 5 Years
Vitamin D is SO SO important.....:)

You should try to get as much of the real stuff from the sun as possible, the supplements help, but not like the real mccoy.....duh SUN.....:vino:
 

Jimi

Diamond Contributor
Member For 5 Years
I’ve been staying out of the sun since I’m really fair skinned, so I figured I’d be deficient. For now I’ll take one a day, then maybe every other day. I’m not really getting that much direct sunlight, though. Hope the D3 will make up for it.


Sent from my iPad using Tapatalk
Regretfully natural from the sun is better but you can do good on supplements...if....you but good quality.
I used to be the same way fair skin but this year my skin was already orange:rolleyes: from all my carrot juice that I was out the first time of the year for over 4 hours bare skin, 11 and 12 hours don't burn me now:bliss:
 

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