Good find, Jimi.....Part Two
Inhibits the survival of cancer cells
Fisetin has also been identified as an anti-mitotic compound, which means this compound found in strawberries stops cancer cell division and thereby prevents cancer cell growth. It does so by targeting, binding to, disrupting, yet also stabilizing aspects of cellular structures called microtubules.
Conventional medicine claims microtubule-targeting drugs have revolutionized cancer treatment. But the body eventually resists them, and like many drugs they also come with many undesirable side effects.
I don’t know if you can eat enough strawberries to equal the anti-mitotic power of the drugs, but maybe you can. Consider this:
Fisetin was found by scientists at the University of Wisconsin, Madison to be the most active microtubule stabilizer among two dozen plant-sourced flavonoids tested and was shown to be "far superior" to the routinely used chemotherapy agent paclitaxel in a lab study of prostate cancer cells.
In their 2016 paper, in which they explored the molecular targets of fisetin in cancer, the Madison team summed up by writing that fisetin interferes with cancer development in multiple ways. It inhibits cancer by promoting apoptosis, modulating autophagy and by impeding a host of cancer cell survival pathways.7
In a separate review, they wrote that fisetin had multiple targets, deterring cancer growth by changing the cell cycle, inducing apoptosis, and inhibiting angiogenesis, invasion, and metastasis.
And it does all this without causing any toxicity to normal cells.
They concluded by writing that "fisetin shows tremendous promise as an anticancer agent."3
Benefits colorectal cancer patients
These findings suggest fisetin would be effective in many types of cancer, and in lab studies this has proved to be the case.
It's effective against cervical, ovarian, lung, prostate, breast, bladder, colorectal, pancreatic, blood and skin cancers in both culture and animal models.
Mouse studies demonstrated a reduction of 67% in the growth of lung cancer8 and melanoma.9
Its potential in human pancreatic cancer was shown when fisetin induced apoptosis, inhibited cell growth and impeded metastasis in a cell line that's highly resistant to currently available chemotherapeutic drugs.10
Studies of lab-grown cells and animal studies aren’t the last word, but there has been at least one human study to date. It was carried out by researchers at Tabriz University of Medical Sciences, Iran in 2018.
In a double-blind, randomized placebo-controlled clinical trial, 37 colorectal cancer patients with an average age of 55, and undergoing chemotherapy, were assigned to receive either 100 mg fisetin for seven consecutive weeks or placebo. The supplementation began one week before chemotherapy and continued until the end of the second chemotherapy cycle.
Compared to the placebo group, there was a significant fall in IL-8, a marker of inflammation. There were also falls in hs-CRP, another marker of inflammation, and in the values of MMP-7, although these were not significantly different from placebo.
The authors concluded that fisetin could improve the inflammatory status of patients with this form of cancer and could act as a novel complementary antitumor agent.11
Getting fisetin every day
Fisetin is found in a wide range of fruits and vegetables such as kiwi fruit, peaches, grapes, tomatoes, onions and cucumbers.
Higher levels are found in apples and persimmons but by far the largest amounts are to be found in strawberries.
Since fisetin shows such great potential to prevent cancer, it's worth eating organic strawberries regularly.
Organic fruits and vegetables in general contain higher levels of health-benefiting phytochemicals. This likely includes fisetin, so this is another reason to go organic.
Fisetin is also available as a nutritional supplement.
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