GLP-1s, Anhedonia, and the Dopamine Trade-Off with Dr. Robin Berzin |
Jim, I went on a low dose of tirzepatide to move a couple of stubborn cholesterol markers ... and it moved a lot more than that. Two sips into my espresso and my body said no thanks. The same thing happened with the drink I was looking forward to at a friend's dinner party, and in the bedroom, too. I sat down with Dr. Robin Berzin to figure out what was happening. Her read is that GLP-1s work on the same reward circuitry as coffee, alcohol and social media: the nucleus accumbens and the VTA, the parts of the brain that hand out our motivation and our cravings. I have spent years meditating to loosen my grip on craving, and here a drug did it for me in a matter of weeks. But what I got instead felt like the volume turned down across the board, good stuff included. Here's some of what we got into:
I came away from this conversation less interested in whether the drug works and more interested in what it costs. I hope you'll listen in, Jeff |
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yet another method, ive been lucky 12 months free now, its a hard road.
I am truly happy for you my friend, eat right and stay that wayye
yet another method, ive been lucky 12 months free now, its a hard road.


thanks mate, you keep on fightingI am truly happy for you my friend, eat right and stay that way![]()
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your a toughy Jimmi, i found it hard but even going through the accident that resulted in my amputation my thoughts were still on the big issue. its hard for people to understand how it feels without them thankfully having to go through it.I never give up, even though it stage 4 I never give up, so many do, been 11 years now, I put up a pretty good scrap, thank you my friend
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