GLP-1s, Anhedonia, and the Dopamine Trade-Off with Dr. Robin Berzin |
Jim, I went on a low dose of tirzepatide to move a couple of stubborn cholesterol markers ... and it moved a lot more than that. Two sips into my espresso and my body said no thanks. The same thing happened with the drink I was looking forward to at a friend's dinner party, and in the bedroom, too. I sat down with Dr. Robin Berzin to figure out what was happening. Her read is that GLP-1s work on the same reward circuitry as coffee, alcohol and social media: the nucleus accumbens and the VTA, the parts of the brain that hand out our motivation and our cravings. I have spent years meditating to loosen my grip on craving, and here a drug did it for me in a matter of weeks. But what I got instead felt like the volume turned down across the board, good stuff included. Here's some of what we got into:
I came away from this conversation less interested in whether the drug works and more interested in what it costs. I hope you'll listen in, Jeff |
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yet another method, ive been lucky 12 months free now, its a hard road.
I am truly happy for you my friend, eat right and stay that wayye
yet another method, ive been lucky 12 months free now, its a hard road.


thanks mate, you keep on fightingI am truly happy for you my friend, eat right and stay that way![]()
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your a toughy Jimmi, i found it hard but even going through the accident that resulted in my amputation my thoughts were still on the big issue. its hard for people to understand how it feels without them thankfully having to go through it.I never give up, even though it stage 4 I never give up, so many do, been 11 years now, I put up a pretty good scrap, thank you my friend
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BREAKING: Vaccinated People Spread Measles. The CDC, the WHO, and Johns Hopkins Just Said So on the Record. |
| A new peer-reviewed study by CDC, WHO, and Johns Hopkins leadership found that nearly 8 out of every 100 vaccinated people who catch measles pass it to someone else. Almost a third of them had received two doses. And the world has exactly one study, of 137 people, trying to measure how much the vaccine actually reduces onward spread. |
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Freezing extends shelf life, cuts waste, and saves money — but not everything holds up in the cold. See exactly what to freeze with confidence (and what to leave out) for dairy, meat, produce, bread, and more. Read The Full Guide → |
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This week: healthier hairYour hair grows in cycles. What happens when the cycle slows down?The secret to fuller-looking hair may begin with helping more follicles return to their active growth phase. | |||||||||||||
| Happy Saturday! I have another newsletter for you—and this one is about hair. More specifically, it’s about something most of us never think about until the shower drain starts looking a little too full: Your hair’s natural growth cycle. Hair doesn’t grow continuously. Every follicle moves through a repeating pattern of growing, transitioning, resting, and eventually releasing a strand so the next cycle can begin. When that rhythm is healthy, most scalp hairs are actively growing. But a wide range of factors can push more follicles into the resting phase (we'll get into that more below). That’s when the shedding may start to feel impossible to ignore. | |||||||||||||
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Hey Jimi, I recently sat down with my close friend and coworker Alex Leaf, a certified sports nutritionist and researcher, to dive deep into some of the most pervasive nutrition myths out there. What impressed me most about our conversation was his ability to cut through the noise and bring real science to topics that are often clouded by dogma from different dietary camps. We spent hours debunking myths from the low-carb crowd, the vegan community, and mainstream nutrition advice. Alex brings a level of nuance and evidence-based thinking that's rare in the health space. Whether you're confused about protein, worried about cholesterol, or trying to understand why you can't lose weight, this episode has answers backed by actual research. In this podcast, Alex and I discuss:
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Yours in health, |
9 Things Pennsylvanians Need to Know About the State’s New Disease Rules — Comment by September 21Pennsylvania’s Department of Health lost the school-mask case in 2021. Its 502-page disease-rules rewrite gets that power back — in its own words.
9 Things Pennsylvanians Need to Know About the State’s New Disease Rules — Comment by September 21Pennsylvania’s Department of Health lost the school-mask case in 2021. Its 502-page disease-rules rewrite gets that power back — in its own words.
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